Professor David Lotshaw - Faculty

Photo of Professor David Lotshaw

Associate Professor

Educational Background

Ph.D., 1983, State University of New York at Albany
M.A., 1976, Miami University
B.S., 1972, Ohio University

Fields of Interest: Cell physiology, neurobiology

Contact: David P. Lotshaw

Research Interests

  • Functional roles of various ion channel classes in controlling neuronal signaling and hormone/neurotransmitter secretion.
  • Identifying biochemical mechanisms controlling channel activity during metabolic and hormone/neurotransmitter stimulation.
  • Utilizing electrophysiological and biochemical methods to characterize ion channel classes controlling membrane potential behavior in steroidogenic adrenocortical cells
  • Determining biochemical mechanisms modulating channel properties in response to metabolic and hormonal regulators of steroid hormone secretion.

Representative Publications

DP Lotshaw, WS Grayburn, LS Yasui, KW Gasser. 2008. Expression of the two-pore domain potassium channel, TASK-2, in rat pancreatic acinar cell zymogen granule membrane. FASEB J 22, 938

Lotshaw, D.P. (2007) Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels. Cell Biochem. Biophys. 47: 209-256 (2007).

Lotshaw, D.P. (2006) Biophysical and pharmacological characteristics of native two-pore domain TASK channels in rat adrenal glomerulosa cells. J. Membr. Biol. 210: 51-70.

Lotshaw, D.P. 2001. Role of membrane depolarization and T-type Ca2+ channels in angiotensin II and K+ stimulated aldosterone secretion. Molec. Cell. Endocrinology 175:157-171.

Lotshaw, D. P. & Sheehan, K. A. 1999. Divalent cation permeability and blockade of Ca2+-permeant non-selective cation channels in rat adrenal zona glomerulosa cells. Journal of Physiology 514: 397-411.

Lotshaw, D.P. 1998. Human Anatomy & Physiology Laboratory Manual. McGraw Hill Co., 106 pages.

Lotshaw, D.P. 1997. Characterization of angiotensin II-regulated K+ conductance in rat adrenal glomerulosa cells. J. Membrane Biol. 156:261-277.

Lotshaw, D.P. 1997. Effects of K+ channel blockers on K+ channels, membrane potential, and aldosterone secretion in rat adrenal zona glomerulosa cells. Endocrinology 138:4167-4175.

Lotshaw, D.P. & Li, F. (1996) Angiotensin II activation of Ca2+--permeant nonselective cation channels in rat adrenal glomerulosa cells. Am. J. Physiol. 271 C1705-C1715.