Several attempts to define topics taught in BIOS 308

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Outline of topics covered in Genetics (BIOS 308) January 13, 1997

--primarily eukaryotic diploids, secondarily prokaryotic

--segregation--equal contribution form both parents

--dominance: relationship between genotype and phenotype

--independent assortment and gene interaction

--calculating expected numbers of offspring from crosses

--real data: comparing observed aand expected numbers

--pedigree patterns and probabilities of offspring types

--sex determination, sex linkage, sex-associated phenomenon

--linkage: major exception to independent assortment: gene mapping

--meiosis, cell cycle, chromosome structure

--chromosome number variation, non-disjunction

--chromosome structure variations

--prokaryotic genetics topics:

--one gene, one polypeptide; biochemical pathways

--conjugation: time of entry mapping

--transfection: co-transfection mapping

--deletion ampping in bacteriophage

--replication, transcription, RNA processing, translation basics

--mutation: types, rates, DNA repair

--control of gene expression: lac operon

--molecular basis of recombination (?)

--quantitative genetics:

--polygenic inheritance

--phenotype = genotype + environment

--hybrid vigor and inbreeding depresion

--selection and heritability

--population genetics

--Hardy-Weinberg and its conditions

--selection and genetic drift

--inbreeding

 

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Genetics Final Exam Topics

--Variations on 9:3:3:1 ratio (dominance variations and gene interactions)

--forked line approach to figuring offspring phenotype ratios

--binomial equation

--chi-square test for goodness of fit

--pedigree analysis

--Barr bodies, sex determination

--meiosis and non-disjunction

--deletion mapping

--crossing-over in inversions

--segregation of translocation heterozygotes

--3-point testcross mapping

--number of gametes formed by recombination

--conjugation time of entry mapping

--co-transduction mapping

--specialized transduction, lambda life cycle

--complementation test

--biochemical pathways

--basics of DNA structure, replication, transcription, translation, RNA processing

--effects of mutation on molecular level

--tests for mutation

--lac operon genetics

 

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Genetics class skills learned --July 2, 1997

--Mendelian inheritance patterns and extensions: intercross, backcross, testcross; complete, partial, co-dominance; multiple alleles, lethal alleles; 2-gene interactions: epistasis and other patterns; penetrance+expressivity; environmental effects, pleiotropy; forked line and Punnett square

--probabilty and binomial to calculate expected offspring numbers

--chi-square test for goodness-of-fit to model

--sex determination, X-inactivation, role of Y and SRY gene, sex-linked, -limited, -influenced; mitochondria DNA, maternal effect

--pedigree patterns: autosomal dominant and recessive, sex-linked recessive. Determine mode of inheritance and calculate probability of affected offspring, including conditional probability

--mitosis, meiosis, cell cycle, gametogenesis and fertilization in mammals and angiosperms

--non-disjunction, variations in chromosome number; variations in structure