Several attempts to define topics taught in BIOS 308
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Outline of topics covered in Genetics (BIOS 308) January 13, 1997
--primarily eukaryotic diploids, secondarily prokaryotic
--segregation--equal contribution form both parents
--dominance: relationship between genotype and phenotype
--independent assortment and gene interaction
--calculating expected numbers of offspring from crosses
--real data: comparing observed aand expected numbers
--pedigree patterns and probabilities of offspring types
--sex determination, sex linkage, sex-associated phenomenon
--linkage: major exception to independent assortment: gene mapping
--meiosis, cell cycle, chromosome structure
--chromosome number variation, non-disjunction
--chromosome structure variations
--prokaryotic genetics topics:
--one gene, one polypeptide; biochemical pathways
--conjugation: time of entry mapping
--transfection: co-transfection mapping
--deletion ampping in bacteriophage
--replication, transcription, RNA processing, translation basics
--mutation: types, rates, DNA repair
--control of gene expression: lac operon
--molecular basis of recombination (?)
--quantitative genetics:
--polygenic inheritance
--phenotype = genotype + environment
--hybrid vigor and inbreeding depresion
--selection and heritability
--population genetics
--Hardy-Weinberg and its conditions
--selection and genetic drift
--inbreeding
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Genetics Final Exam Topics
--Variations on 9:3:3:1 ratio (dominance variations and gene interactions)
--forked line approach to figuring offspring phenotype ratios
--binomial equation
--chi-square test for goodness of fit
--pedigree analysis
--Barr bodies, sex determination
--meiosis and non-disjunction
--deletion mapping
--crossing-over in inversions
--segregation of translocation heterozygotes
--3-point testcross mapping
--number of gametes formed by recombination
--conjugation time of entry mapping
--co-transduction mapping
--specialized transduction, lambda life cycle
--complementation test
--biochemical pathways
--basics of DNA structure, replication, transcription, translation, RNA processing
--effects of mutation on molecular level
--tests for mutation
--lac operon genetics
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Genetics class skills learned --July 2, 1997
--Mendelian inheritance patterns and extensions: intercross, backcross, testcross; complete, partial, co-dominance; multiple alleles, lethal alleles; 2-gene interactions: epistasis and other patterns; penetrance+expressivity; environmental effects, pleiotropy; forked line and Punnett square
--probabilty and binomial to calculate expected offspring numbers
--chi-square test for goodness-of-fit to model
--sex determination, X-inactivation, role of Y and SRY gene, sex-linked, -limited, -influenced; mitochondria DNA, maternal effect
--pedigree patterns: autosomal dominant and recessive, sex-linked recessive. Determine mode of inheritance and calculate probability of affected offspring, including conditional probability
--mitosis, meiosis, cell cycle, gametogenesis and fertilization in mammals and angiosperms
--non-disjunction, variations in chromosome number; variations in structure