Professor Ana M. Calvo

Photo of Dr. Ana Calvo

Presidential Research Professor

Educational Background

Ph.D., Apto Cum Laude, CIB-CSIC/University of Alcala de Henares, Madrid, Spain (Microbiology), 1995

M.S., University of Alcala de Henares, Madrid, Spain(Microbiology and Parasitology) 1989

B.S., University of Alcala de Henares, Madrid, Spain (Biological Science) 1987

Contact: Ana M. Calvo
amcalvo@niu.edu
Office: MO 341, (815) 753-0451
Lab: (815) 753-1468
Depart. of Biological Sciences
Northern Illinois University

Additional Experience

Postdoctoral stay (Molecular Microbiology September-December 2001). Michigan State University, East Lansing, MI

Postdoctoral stay (Molecular Microbiology-Functional Genomics July-August 2001) Texas A&M University, College Station, TX

Postdoctoral Stay (Molecular Microbiology 1996-June 2001). Texas A&M University, College Station, TX

Research Specialization:

Molecular Studies of Agriculturally and Medically Important Fungi

More about the Calvo Lab…

Photo of Calvo Lab

Dr. Calvo with Lab Group - click to view larger

Representative Publications

Baidya S, Duran R, Lohmar JM, Harris-Coward PY, Cary JW, Hong SY, Roze LV, Linz JE, Calvo AM. VeA is associated with the response to oxidative stress in the aflatoxin-producer Aspergillus flavus. Eukaryot Cell. 2014 Jun 20. pii: EC.00099-14. [Epub ahead of print]

Heddergott C, Calvo AM, Latgé JP. The volatome of Aspergillus fumigatus. Eukaryot Cell. 2014 Jun 6. pii: EC.00074-14. [Epub ahead of print]

Lan N, Zhang H, Hu C, Wang W, Calvo AM, Harris SD, Chen S, Li S. Coordinated and Distinct Functions of Velvet Proteins in Fusarium verticillioides. Eukaryot Cell. 2014 Jul;13(7):909-18. doi: 10.1128/EC.00022-14. Epub 2014 May 2.

Smith TD, Calvo AM. The mtfA Transcription Factor Gene Controls Morphogenesis, Gliotoxin Production and Virulence in the Opportunistic Human Pathogen Aspergillus fumigatus. Eukaryot Cell. 2014 Apr 11. [Epub ahead of print]

Duran RM, Gregersen S, Smith TD, Bhetariya PJ, Cary JW, Harris-Coward PY, Mattison CP, Grimm C, Calvo AM. The role of Aspergillus flavus veA in the production of extracellular proteins during growth on starch substrates. Appl Microbiol Biotechnol. 2014 Mar 4. [Epub ahead of print]

Lin H, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, Chooi YH, Cane DE, Calvo AM, Watanabe K, Tang Y. Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway. J Am Chem Soc. 2014 Feb 26. [Epub ahead of print]

Cary JW, Harris-Coward PY, Ehrlich KC, Di Mavungu JD, Malysheva SV, De Saeger S, Dowd PF, Shantappa S, Martens SL, Calvo AM. Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment. Fungal Genet Biol. 2014 Mar;64:25-35.

Cary JW, Harris-Coward PY, Ehrlich KC, Mavungu JD, Malysheva SV, Saeger SD, Dowd PF, Shantappa S, Martens SL, Calvo AM. 2014. Functional characterization of a veA-dependent polyketide synthase gene in Aspergillus flavus necessary for the synthesis of asparasone, a sclerotium-specific pigment.  Fungal Genetics and Biology Jan 8. pii: S1087-1845(14)00002-4. doi: 10.1016/j.fgb.2014.01.001

Dhingra, S, Lind, AL, Lin H-C,Tang Y, Rokas A and Calvo AM. 2013. The fumagillin gene cluster, an example of hundreds of genes under veA control in Aspergillus fumigatus. PLoS One. http://dx.plos.org/10.1371/journal.pone.0074122.

Ramamoorthy V, Dhingra S, Kincaid A, Shantappa S, Feng X, Calvo AM. The putative C2H2 transcription factor MtfA is a novel regulator of secondary metabolism and morphogenesis in Aspergillus nidulans. PLoS One. 2013 Sep 16;8(9):e74122. doi: 10.1371/journal.pone.0074122

Shantappa S, Dhingra S, Hernández-Ortiz P, Espeso EA, Calvo AM 2013. Role of the Zinc Finger Transcription Factor SltA in Morphogenesis and Sterigmatocystin Biosynthesis in the Fungus Aspergillus nidulans. PLoS One. Jul 1;8(7):e68492. doi: 10.1371

Lin HC, Chooi YH, Dhingra S, Xu W, Calvo AM, Tang Y. J. 2013. The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. Am Chem Soc. Mar 27;135(12):4616-9.

Palmer JM, Theisen JM, Duran RM, Grayburn WS, Calvo AM, Keller NP. 2013. Secondary metabolism and development is mediated by LlmF control of VeA subcellular localization in Aspergillus nidulans. PLoS Genet. 2013;9(1):e1003193.

Dhingra S., Andes D., Calvo A.M.2012. VeA Regulates Conidiation, Gliotoxin Production and Protease Activity in the Opportunistic Human Pathogen Aspergillus fumigatus.  Eukaryotic Cell. In press.

Cary JW, Harris-Coward PY, Ehrlich KC, Mack BM, Kale SP, Larey C, Calvo AM. 2012. NsdC and NsdD Affect Aspergillus flavus Morphogenesis and Aflatoxin Production. Eukaryot Cell. 11:1104-11

Laskowski-Peak MC, Calvo AM, Rohrssen J, Smulian GA. 2012. VEA1 is required for cleistothecial formation and virulence in Histoplasma capsulatum. Fungal Genet.Biol. [Epub ahead of print]

Si H, Rittenour WR, Xu K, Nicksarlian M, Calvo AM, Harris SD. 2012. Morphogenetic and developmental functions of the Aspergillus nidulans homologues of the yeast bud site selection proteins Bud4 and Axl2. Mol Microbiol. 85:252-70.

Myung, K., N. C. Zitomer, M. Duvall, A. E. Glenn, R. T. Riley and A. M. Calvo. 2012. The conserved global regulator VeA is necessary for symptom production and mycotoxin synthesis in maize seedlings by Fusarium verticillioides. Plant Pathology. 61:152-160

Ramamoorthy V, Shantappa S, Dhingra S, Calvo AM. 2012. veA-dependent RNA-pol II transcription elongation factor-like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans. Mol Microbiol. 85:795-814.

Laskowski-Peak MC, Calvo AM, Rohrssen J, Smulian GA. 2012. VEA1 is required for cleistothecial formation and virulence in Histoplasma capsulatum. Fungal Genet.Biol. [Epub ahead of print]

Padamsee M, Kumar TK, Riley R, Binder M, Boyd A, Calvo AM, Furukawa K, Hesse C, Hohmann S, James TY, LaButti K, Lapidus A, Lindquist E, Lucas S, Miller K, Shantappa S, Grigoriev IV, Hibbett DS, McLaughlin DJ, Spatafora JW, Aime MC. 2012.  The genome of the xerotolerant mold Wallemia sebi reveals adaptations to osmotic stress and suggests cryptic sexual reproduction. Fungal Genet Biol. 49:217-26.

Chettri P, Calvo AM, Cary JW, Dhingra S, Guo Y, McDougal RL, Bradshaw RE. 2012. The veA gene of the pine needle pathogen Dothistroma septosporum regulates sporulation and secondary metabolism. 49:141-51.

Calvo AM and Dhingra S. 2011. Conserved regulatory mechanisms controlling aflatoxin and sterigmatocystin biosynthesis. In: Aflatoxin-Biochenistry and Molecular Biology. Ed.: Ramon G. Guevara-Gonzalez. pg 67-89. ISBN 978-953-307-395-8.

Baidya S, Cary JW, Grayburn WS, Calvo AM. 2011. Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production. Appl. Environ. Microbiol. 77:5524-8.

Atoui A, Kastner C, Larey CM, Thokala R, Etxebeste O, Espeso EA, Fischer R, Calvo AM 2010. Cross-talk between light and glucose regulation controls toxin production and morphogenesis in Aspergillus nidulans. Fungal Genet Biol. 2010 Sep 17. [Epub ahead of print]

Duran R.M., Cary J.W, Calvo A.M. 2010. Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi.  Toxins,  2: 367-381

Chanda A., Roze, L., Kang S., Hicks G., Railhel., N., Calvo A., Linz J. 2009. A key role for vesicles in fungal secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. Proc Natl Acad Sci U.S.A. Nov 17; 106:19533-8.

Duran RM, Cary JW and Calvo AM. 2009. The role of veA on Aspergillus flavus infection of peanuts, corn and cotton. Open Mycology journal (open access) 3, 27-36. .pdf

Myung K, Li S, Butchko RAE,Busman M, Proctor RH, Abbas HK, Calvo AM. 2009. FvVE1 regulates biosynthesis of the mycotoxins fumonisins and fusarins in Fusarium verticillioides. J. Agric. Food Chem. [epub ahead of print]

Araújo-Bazán L, Dhingra S, Chu J, Fernández-Martínez J, Calvo AM, Espeso EA 2009. Importin alpha is an essential nuclear import carrier adaptor required for proper sexual and asexual development and secondary metabolism in Aspergillus nidulans. Fungal Genet Biol. Mar 24. [Epub ahead of print]

Cary J, Szernzen L, and Calvo AM. 2009. Regulation of Aspergillus flavus aflatoxin biosynthesis and development. In Mycotoxin Prevention and control in Agriculture. Eds.: David Kendra and Michael Appell. pg. 183-203.

Cary J and Calvo AM. 2008. Regulation of aflatoxin biosynthesis. Journal of Toxicology: Toxin Reviews. 27: 347-370.

Li S., Calvo AM, Yuen GY, Du L Harris SD. 2008. Induction of Cell Wall Thickening by the Antifungal Compound Dihydromaltophilin Disrupts Fungal Growth and Is Mediated by Sphingolipid Biosynthesis. Journal of Eukaryotic Microbiology, 56: 182-187.

Calvo A.M. 2008. The VeA regulatory system and its role in morphological and chemical development in fungi. Fungal Genetics and Biology 45:1053-61.

Atoui A, Bao D, Kaur N., Grayburn WS, Calvo AM. 2008. The MAP-kinase mpkB is necessary for normal secondary metabolism in Aspergillus nidulans. Appl. Environ. Microbiol. 74:3596-600.

Purschwitz J, Müller S, Kastner C, Schöser M, Haas H, Espeso EA, Atoui A, Calvo AM, Fischer R. 2008. Functional and Physical Interaction of Blue- and Red-Light Sensors in Aspergillus nidulans. Current Biology 18:255-9.

Roze LV, Beaudry RM, Arthur AE, Calvo AM, Linz JE. 2007. Aspergillus volatiles regulate aflatoxin synthesis and asexual sporulation in Aspergillus parasiticus. Appl Environ Microbiol. 73:7268-76.

Paoletti M, Seymour FA, Alcocer MJ, Kaur N, Calvo AM, Archer DB, Dyer PS. 2007. Mating Type and the Genetic Basis of Self-Fertility in the Model Fungus Aspergillus nidulans. Curr Biol. Jul 30 [Epub ahead of print] pdf

Cary JW, Obrian GR, Nielsen DM, Nierman W, Harris-Coward P, Yu J, Bhatnagar D, Cleveland TE, Payne GA, Calvo AM. 2007. Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics. Appl Microbiol Biotechnol. Jul 24 [Epub ahead of print] pdf

Li S, Bao D, Yuen G, Harris SD, Calvo AM. 2007. basA regulates cell wall organization and asexual/sexual sporulation ratio in Aspergillus nidulans. Genetics. 176:243-53 pdf

Stinnet S., Espeso E., Cobeno L., Arujo-Bazan L. and Calvo A.M. 2007. VeA subcellular localization is dependent on the improtin alpha carrier and on light in the filamentous fungus Aspergillus nidulans. Molecular Microbiology. 63:242-55. Epub 2006 Dec 5.

Cary JW, Ehrlich K, Kale SP, Calvo A.M., Bhatnagar D, Cleveland TE. 2006. Regulatory Elements in Aflatoxin Biosynthesis. Mycotoxin Research 22:105-109

Li S., Myung K., Guse D., Donkin B., Proctor RH, Grayburn W.S. and Calvo A.M. 2006. FvVE1 regulates filamentous growth, the ratio of microconidia to macroconidia and cell wall formation in Fusarium verticillioides. Molecular Microbiology. 62:1418-32. Epub 2006 Oct 18.

Duran R.M., Cary J. W. and Calvo A.M. 2006. Production of Cyclopiazonic acid, Aflatrem and Aflatoxin by Aspergillus flavus is regulated by veA, a gene necessary for sclerotial formation. Applied Microbiology and Biotechnology. 73:1158-68. Epub Sep 19.

Calvo A.M., Bok J.W., Brooks W. and Keller N.P 2004. veA is required for toxin and sclerotial production in Aspergillus parasiticus. Apply Environmental Microbiology 70:4733-9. pdf

Wilson R.A., Calvo A.M., Chang P-K and Keller N.P. 2004. Characterization of the Aspergillus parasiticus delta12-desaturase gene: a role for lipid metabolism in the Aspergillus/plant interaction. Microbiology. 150:2881-8. pdf

Calvo A.M. 2004. Mycotoxins. In: Toxins in Food. Dabrowsky W. and Sikorski Z. (Eds.) CRC Press. Boca Raton, Florida, pg 215-237

Roze L.V., Calvo A.M., Gunterus A., Beaudry R., Kall M., and Linz J.E. 2004. Ethylene modulates development and toxin biosynthesis in Aspergillus likely via an ethylene sensor-mediated signaling pathway. Journal of Food Protection. 67: 438-447.

Kato N., Brooks W. and Calvo A.M. 2003. The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans. Eukaryotic Cell. 2: 1178-1186. pdf

Calvo A.M., Wilson R.A., Bok J. and Keller N.P. 2002. Relationship between natural product metabolism and fungal development. Microbiology and Molecular Biology Reviews. 66:447-59. pdf

Calvo A.M., Gardner H.W. and Keller N.P. 2001. Genetic connection between fatty acid metabolism and sporulation in Aspergillus nidulans. Journal of Biological Chemistry. 276:25766-74 pdf

Calvo A.M, Hinze L.L., Gardner H.W. and Keller N.P. 1999. Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. Applied and Environmental Microbiology. 65:3668-3673 pdf

Calvo A.M., Desjardins A., Keller N.P. and Trail, F. 1999. Effects of the plant lipid metabolite CP2 on morphological development and biosynthesis of natural products in Aspergillus spp. In preparation.

Calvo A.M., Copa-Patiño J.L., Alonso A. and González A.E. 1998. Studies of the production and characterization of laccase activity in the basidiomycete Coriolopsis gallica, an efficient decolorizer of alkaline effluents. Archives of Microbiology, 171:31-36

Calvo A.M., Terrón M.C., Fidalgo M.L., Pelayo J.M., Galletti G.C. and González A.E. 1995. Py-GC-MS Characterization of wheat straw alkaline-cooking effluents after biological treatment with the fungi Phanerochaete chrysosporium and Ganoderma australe. Analytical Chimica Acta, 309:145-152

Calvo A.M., Galletti G.C. and González A.E. 1995. Paper wastewater analyses by Py/GC/MS during biological treatment with the fungi Coriolopsis gallica and Paecilomyces variotii. Journal of Analytical and Applied Pyrolisis, 33:39-50

Pal M., Calvo A.M., Terrón M.C. and González A.E. 1995. Changes produced in the integral sugarcane bagasse after SSF by the edible mushroom Flammulina velutipes and the white-rot fungus Trametes versicolor. World Journal of Microbiology and Biotechnology, 11:541-545

Terron M.C., Calvo A.M., Fidalgo M.L., Manzanares P., Ballesteros M., Martinez A.T., Martin C. and Gonzalez A.E. 1992. Chemical characterization and biological decolorization of straw soda pulping effluents.   Eds. M. Kuwahara and M. Shimada.  Biotechnology in Pulp and Paper Industry, Uni Publishers Co., Ltd., Kyoto, Japan.  pp 51-56.

Calvo A.M., Martinez A.T. and Gonzalez A.E. 1991. Biological decolorization of effluent from paper industry by fungi. Med. Fac. Landbouww. 56: 1565-1567.

Jimenez A., Rodriguez F., Calvo A.M. and Casado N. 1989. A comparative study of malate dehydrogenase in the genus Trichinella.  Trichinellosis-ITC 7, Ed. C. Tanner, CSIC Press, Madrid, Spain.  pp 53-58.

Kato N., Brooks W. and Calvo A.M. The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans. Eukaryotic Cell.2003; 2: 1178-1186. pdf

Calvo A.M., Wilson R.A., Bok J. and Keller N.P. 2002. Relationship between natural product metabolism and fungal development. Microbiology and Molecular Biology Reviews. 66:447-59. pdf

Calvo A.M., Gardner H.W. and Keller N.P. 2001. Genetic connection between fatty acid metabolism and sporulation in Aspergillus nidulans. Journal of Biological Chemistry, 276:25766-74 pdf

Calvo A.M, Hinze L.L., Gardner H.W. and Keller N.P. 1999. Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. Applied and Environmental Microbiology, 65:3668-3673 pdf

Calvo A.M., Desjardins A., Keller N.P. and Trail, F. Effects of the plant lipid metabolite CP2 on morphological development and biosynthesis of natural products in Aspergillus spp. In preparation.

Calvo A.M., Copa-Patiño J.L., Alonso A. and González A.E. 1998. Studies of the production and characterization of laccase activity in the basidiomycete Coriolopsis gallica, an efficient decolorizer of alkaline effluents. Archives of Microbiology, 171:31-36

Calvo A.M., Terrón M.C., Fidalgo M.L., Pelayo J.M., Galletti G.C. and González A.E. 1995. Py-GC-MS Characterization of wheat straw alkaline-cooking effluents after biological treatment with the fungi Phanerochaete chrysosporium and Ganoderma australe. Analytical Chimica Acta, 309:145-152

Calvo A.M., Galletti G.C. and González A.E. 1995. Paper wastewater analyses by Py/GC/MS during biological treatment with the fungi Coriolopsis gallica and Paecilomyces variotii. Journal of Analytical and Applied Pyrolisis, 33:39-50

Pal M., Calvo A.M., Terrón M.C. and González A.E. 1995. Changes produced in the integral sugarcane bagasse after SSF by the edible mushroom Flammulina velutipes and the white-rot fungus Trametes versicolor. World Journal of Microbiology and Biotechnology, 11:541-545

Terron M.C., Calvo A.M., Fidalgo M.L., Manzanares P., Ballesteros M., Martinez A.T., Martin C. and Gonzalez A.E.  Chemical characterization and biological decolorization of straw soda pulping effluents.   Eds. M. Kuwahara and M. Shimada.  Biotechnology in Pulp and Paper Industry, Uni Publishers Co., Ltd., Kyoto, Japan. 1992.  pp 51-56.

Calvo A.M., Martinez A.T. and Gonzalez A.E.  Biological decolorization of effluent from paper industry by fungi. Med. Fac. Landbouww. 1991.  56: 1565-1567.

Jimenez A., Rodriguez F., Calvo A.M. and Casado N.  1989. A comparative study of malate dehydrogenase in the genus Trichinella.  Trichinellosis-ITC 7, Ed. C. Tanner, CSIC Press, Madrid, Spain.  pp 53-58.