Professor W. Ellwod Briles - Faculty

Photo of Dr. and Mrs. Briles

Mrs. Ruth Briles (left) and Dr. Elwood Briles (right)

Educational Background

Ph.D., 1948, University of Wisconsin

B.A., 1941, University of Texas 

Fields of Interest: Immunology; immunogenetics; molecular genetics 

Contact: W. Elwood Briles 
Dept. Biological Sciences
Northern Illinois University 
DeKalb, IL 60115-2861
Office: 815-753-7840, MO415

Publications/Curriculum Vitae

Representative Publications

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Banat GR, Tkalcic S, Dzielawa JA, Jackwood MW, Saggese MD, Yates L, Kopulos R, Briles WE, Collisson EW.  2013.  Association of the chicken MHC B haplotypes with resistance to avian coronavirus.  Developmental and Comparative  Immunology. Apr;39(4):430-7.

Bauer  MM, Miller MM, Briles WE, Reed KM.  2013.  Genetic variation at the MHC in a population of introduced wild turkeys.  Animal Biotechnology. 24(3):210-28.

Goto RM, Wang Y, Taylor RL Jr, Wakenell PS, Hosomichi K, Shiina T, Blackmore CS, Briles WE, Miller MM.  2010.  BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken.  Proc Natl Acad Sci U S A. 106(39):16740-5. Erratum in: Proc Natl Acad Sci U S A 107(17):8041.

Singh S, Briles W.E., Lupiani B, Collisson EW.  2010.  Avian influenza viral nucleocapsid and hemagglutinin proteins induce chicken CD8+ memory T lymphocytes.  Virology 10;399(2):231-8.

Singh S, Toro H, Tang DC, Briles W.E., Yates LM, Kopulos RT, Collisson EW.  2010.  Non-replicating adenovirus vectors expressing avian influenza virus hemagglutinin and nucleocapsid proteins induce chicken specific effector, memory and effector memory CD8(+) T lymphocytes.  Virology 15;405(1):62-9.

Ronald M. Goto,Yujun Wang, Robert L. Taylor, Jr., Patricia S. Wakenell, Kazuyoshi Hosomichi, Takashi Shiina, Craig S. Blackmore, W. Elwood Briles, and Marcia M. Miller. 2009. BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken. PNAS. In Press.

E.S. Schulten, W. E. Briles, and R. L. Taylor, Jr., 2009. Rous sarcoma growth in lines congenic for major histocompatibility (B) complex recombinants. Poultry Science 88:1601-1607 doi:10.3382/ps.2009-00085.

Shiina, T., Briles, W.E., Goto, R.M., Hosomichi, K., Yanagiya, K., Shimizu, S., Inoko, H., and Miller, M.M. 2007. Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease. Journal of Immunology 178:7162-7172.

Collisson, E.W., S.H. Seo, J. Dzielawa, W.E. Briles, and J. Pei. 2001. Syngeneic DC8+, T, lymphocytes protect chicks from acute infectious bronchitis viral infections and respiratory illness. In: K.A. Schat (ed.), Current Progress on Avian Immunology Research, pp. 220-225. American Association of Avian Pathologists, Kennett Square, Pennsylvania.

Briles, W.E. 2001. Design of parent stocks facilitating simultaneous testing of ultiple alloantigen systems for immune response. In: K.A. Schat (ed.) Current Progress on Avian Immunology Research, pp. 177-181. American Association of Avian Pathologists, Kennett Square, Pennsylvania.

Briles, W.E. 2001. Historical reivew of developments characterizing the B blood group system. In: K.A. Schat (ed.) Current Progress on Avian Immunology Research, pp. 155-161. American Association of Avian Pathologists, Kennett Square, Pennsylvania.

Medarova, A., W.E. Briles and R.L. Taylor, Jr. 2001. The effects of alloantigen system L on the fate of Rous sarcomas. In: K.A. Schat (ed.) Current Progress on Avian Immunology Research, pp. 215-219. American Association of Avian Pathologists, Kennett Square, Pennsylvania.

Senseney, H.L., H. Abplanalp, W.E. Briles and R.L. Taylor, Jr. 2001. Complementation between BQ and B17 MHC haplotypes increases Rous sarcoma regression. In: K.A. Schat (ed.) Current Progress on Avian Immunology Research, pp. 211-214. American Association of Avian Pathologists, Kennett Square, Pennsylvania.

LePage, K.T., W.E. Briles, F. Kopti and R.L. Taylor, Jr. 2000. Non-major histocompatibility complex effects on the fate of Rous sarcomas. Poultry Science 79:343-348. 

LePage, K.T., M.M. Miller, W.E. Briles and R.L. Taylor, Jr. 2000. Rfp-Y genotype affects the fate of Rous sarcomas in B2B5 chickens. Immunogenetics 51:751-754. 

Qureshi, M.A., R.A. Ali, L.N. Thomas, R.N. Baloch and W.E. Briles. 2000. Alloantigen systems L and P influence phagocytic function independent of the major histocompatibility complex (B) in chickens. Poultry Science 79:1271-1275. 

Kopti, F., S.L. Stevens, and W.E. Briles. 1999. Developmental expression of alloantigen systems in the chicken. Developmental & Comparative Immunology 23:617-627. 

Drake, B.M., R.M. Goto, M.M. Miller, G.F. Gee, and W.E. Briles. 1999. Molecular and immunogenetic analysis of major histocompatibility haplotypes in northern bobwhite enable direct identification of corresponding haplotypes in an endangered subspecies, the masked bobwhite. Zoo Biology 18:279-294. 

Maxey, G.D., E.M. Hollerman and W.E. Briles. 1997. Phenotypic variability in pedigreed families of goldfish revealed by alloantisera and agglutination assays. Journal of Aquatic Animal Health 9:49-57.

Kopti, F., R.W. Briles and W.E. Briles. 1997. Immunogenetics of the A-E alloantigen complex. Poultry Science 76:1688-1697.Jarvi, S.J., R.M. Goto, G.F. Gee, W.E. Briles, and M.M. Miller. 1999. Identification, inheritance, and linkage of B-G-like and MHC class genes in cranes. Journal of Heredity 90:152-159. 

Jarvi, S.I., R.M. Goto, W.E. Briles, and M.M. Miller. 1996. Characterization of Mhc genes in a multigenerational family of ring-necked pheasants. Immunogenetics 43:125-135.

Miller, M.M., R. Goto, R.L. Taylor, Jr., R. Zoorob, C. Auffray, R.W. Briles, W.E. Briles, and S.E. Bloom. 1996. Assignment of Rfp-Y to the chicken major histocompatibility complex/NOR microchromosome and evidence for high-frequency recombination associated with the nucleolar organizer region. Proc. Natl. Acad. Sci. USA 93:3958-3962.

Wakenell, P.S., M.M. Miller, R.M. Goto, W.J. Gauderman and W.E. Briles 1996. Association between the Rfp-Y haplotype and the incidence of Marek's disease in chickens. Immunogenetics 44:242-245.   

Research Interests

Photo of research chickens
Current research deals with the expression of genes through cell-surface antigens, cell surface control of susceptibility and resistance to oncogenic viruses, immune response to neoplastic tissue, and genetic fine structure of the major histocompatibility complex (MHC) in the chicken.